Contributions to time series data mining towards the detection of outliers/anomalies

148 p.Los recientes avances tecnológicos han supuesto un gran progreso en la recogida de datos, permitiendo recopilar una gran cantidad de datos a lo largo del tiempo. Estos datos se presentan comúnmente en forma de series temporales, donde las observaciones se han registrado de forma cronológica y están correlacionadas en el tiempo. A menudo, estas dependencias temporales contienen información significativa y útil, por lo que, en los últimos años, ha surgido un gran interés por extraer dicha información. En particular, el área de investigación que se centra en esta tarea se denomina minería de datos de series temporales.La comunidad de investigadores de esta área se ha dedicado a resolver diferentes tareas como por ejemplo la clasificación, la predicción, el clustering o agrupamiento y la detección de valores atípicos/anomalías. Los valores atípicos o anomalías son aquellas observaciones que no siguen el comportamiento esperado en una serie temporal. Estos valores atípicos o anómalos suelen representar mediciones no deseadas o eventos de interés, y, por lo tanto, detectarlos suele ser relevante ya que pueden empeorar la calidad de los datos o reflejar fenómenos interesantes para el analista.Esta tesis presenta varias contribuciones en el campo de la minería de datos de series temporales, más específicamente sobre la detección de valores atípicos o anomalías. Estas contribuciones se pueden dividir en dos partes o bloques. Por una parte, la tesis presenta contribuciones en el campo de la detección de valores atípicos o anomalías en series temporales. Para ello, se ofrece una revisión de las técnicas en la literatura, y se presenta una nueva técnica de detección de anomalías en series temporales univariantes para la detección de fugas de agua, basada en el aprendizaje autosupervisado. Por otra parte, la tesis también introduce contribuciones relacionadas con el tratamiento de las series temporales con valores perdidos y demuestra su aplicabilidad en el campo de la detección de anomalías

Gizarte digitalerako hezkuntza: adimen artifizialaren eta big dataren erabilerarantz

Gizartean izan den iraultza teknologikorik eraldakorrenaren testigu gara; une oro aldatzen eta berreraikitzen den gizarte baten iraultza ezplanifikatuaren testigu. Espazioa globalizatuz eta deslokalizatuz doa; halatan, mikroistorio, mikrokultura eta mikrosegundoen aroa sortu da, mikrolanetarako eta gig-ekonomiarako sarbidea emango diguna. Eredu berri horretan, mezu hipermediatiko eta hipertestualak eraikitzeko kultura nagusitu da, zeinak sortzez jada digitalak baitira. Baina ez hori bakarrik: gure pentsamenduan ere (er)aldaketa gertatu da, eta pentsamendu bisual eta pentsamendu konputazional baten aurrean kokatzen da gizartea

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Impaired control of multiple viral infections in a family with complete IRF9 deficiency

14 p.-5 fig.-5 tab.Supported by grants SAF2014-58752-R and SAF2017-83265-R (to H.T.R.), SAF2017-83785-R (to A.D.-S.; MINECO/AEI/FEDER, UE), and a PhD studentship to A.B.M. (MINECO, SVP-2014-068263). E.L.-G. has grants from the Spanish Association Against Cancer (AECC) and Carlos III Health Institute PI16/01605).Peer reviewe

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry.

AimTo determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW).MethodsObservational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality.ResultsAs of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; pConclusionsHospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective